Researchers in the USA sought to determine alternative medication use in a neurology clinic population and to predict patients likely to use alternative medications. They surveyed 216 adults presenting to a university-affiliated neurology clinic. Subjects were questioned regarding diagnosis, medications, satisfaction with medications, alternative medications and demographics. Alternative medications were defined as herbal therapies, holistic therapies, minerals, or vitamins other than multiple vitamins. The most frequent conditions seen in all subjects were headache, epilepsy and stroke. Mean ratings of patients’ satisfaction with their conventional medications and health were 6.8 ± 2.64 and 6.4 ± 2.23 on a 10-point scale, respectively. Of the subjects, 40 were taking alternative therapies. Regression analysis suggests that patients with higher levels of education are more likely to use alternative therapies.