Skip navigation
FACT
Focus on Alternative and Complementary Therapies

A double-blinded, randomised controlled assessment of the effects of 0.6–1.6 μm stellate ganglion irradiation in normal subjects and people with Complex Regional Pain Syndrome 1 (CRPS 1)

Basford JR1, Low P2, Sandroni P2
1Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA
2Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA

Objective

Stellate ganglion blocks are an effective treatment of upper extremity pain, but are invasive and involve a significant risk of morbidity. Linearly polarised red light is promoted as a safe alternative to this procedure, but its effects are poorly established. The purpose of this study was to: (1) to assess the physiological effects of this approach in normal subjects and people with complex regional pain syndrome (CRPS) 1 and (2) to quantify the presence, intensity and duration of its benefits.

Materials and methods

This study involved two phases. In the first phase, six adults (ages 18–60 years) with normal neurological examinations underwent transcutaneous irradiation of the right stellate ganglion with a linearly polarised 0.6–1.6 μm Iodine lamp (480 s; probe diameter 0.7 cm; duty cycle 1s on, 4s off; ‘on’ beam intensity 3.90 W/cm2). The second phase involved a double-blinded evaluation of 12 subjects (ages 18–72 years): six with CRPS 1 of an upper extremity and six ‘neurologically normal’ age and gender-matched controls. At their first session, subjects and their controls were randomised to receive either active (as described above) or placebo irradiation. Assignments were reversed a week later. Upper extremity temperatures as well as sudomotor and vasomotor function were assessed before treatment and for 30-min following irradiation. Analgesic benefits were assessed over the same period as well as one week following treatment.

Results

Phase one: Subjects could not detect the beam. There were no adverse consequences. Phase two: Data collection is complete for five of six CRPS–control subject pairs. Data collection and analysis will be concluded prior to the conference.

Conclusion

Irradiation is well tolerated. Physiological effects and treatment benefit will be discussed.

Top | Next: The effects of homoeopathic therapy on health-related quality of life»
© Pharmaceutical Press 2007
Accessibility | Terms and Conditions