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FACT
Focus on Alternative and Complementary Therapies

Can psychological interventions prolong the life of cancer patients? A systematic review of randomised controlled trials

Schmidt K, Ernst E
Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter, EX2 4NT, UK

Objective

The aim of this systematic review was to determine whether effects of psychological support (e.g. reintegration programmes, counselling, psychotherapy as well as social and psycho-educational support) prolong the life of cancer patients.

Materials and methods

The following databases were searched: the Cochrane Controlled Trials Register (CENTRAL/CCTR), Medline (via PubMed), Amed, EMBASE, PsychInfo, Cancerlit and CINAHL. The primary outcome was survival and all randomised controlled trials with this endpoint were considered. Hard copies of relevant papers were retrieved and data were extracted independently by both authors. Odds ratios and P-values obtained through standard statistical software were calculated.

Results

Eleven randomised controlled trials with a total sample size of 1508 patients were included. Eight did not show a survival benefit for psychological interventions. Three randomised controlled trials suggested that psychological interventions could positively influence survival. The pooled data yielded an odds ratio of 0.89, p = 0.6 (confidence interval 0.59–1.35).

Conclusion

The majority of the rigorous studies suggest that psychological therapies do not have a positive effect on the length of survival of cancer patients. The pooled data from the 11 rigorous studies available to date do not suggest an effect on survival.

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