A total of 500 female outpatients were interviewed by healthcare practitioners using a botanical/drug history questionnaire. Respondents were 46.8% African American, 39.6% Caucasian, 11.7% Hispanic and 1.5% Asian, with a mean age of 50.34 years. Botanical dietary supplements (BDS) were used by 79% of respondents (n = 395), of which 36.5% used BDS daily. Of the positive respondents, 51.7% used one or two BDS, whereas 48.4% used three or more. Commonly used botanicals included soy (42%), Camellia sinensis (green tea) (34.68%), Chamomilla spp. (chamomile) (20.76%), Gingko biloba (20.51%), ginseng (17.97%), Echinacea spp. (15.44%), and Hypericum perforatum (St John’s wort) (7.34%). Cimicifuga racemosa (black cohosh), Allium sativum (garlic), Trifolium pratense (red clover), Piper methysticum (kava), Valeriana officinalis (valerian), Oenothera biennis (evening primrose) and Ephedra sinica were used by less than 15% of respondents. Efficacy ratings were high for BDS, and 68% claimed to have no side-effects. Only 3% of respondents obtained BDS information from healthcare professionals and 70% of respondents were not informing their physician of BDS use.