One of the ingredients most commonly found in Ayurvedic arthritis formulae is guggul, an oleoresin of the herb Commiphora mukul. This study was conducted using an outcome, quasi-experimental, model. A total of 30 participants suffering from osteoarthritis, with a score of 2 or more on the Kellegran–Lawrence scale for at least one knee, were admitted. Commiphora mukul was administered in capsule form (500 mg concentrated exact delivered t.i.d.) along with food. The WOMAC Total Score was used as a primary outcome measure; VAS scales, 6-minute walk-test, and WOMAC subscales were used as outcome measures. At the end of treatment, there was a significant difference in the scores of the primary and secondary outcome measures. On the primary measure, WOMAC total score, participants were significantly improved after taking the supplement for 1 month and continued to improve at the 2-month marker and follow-up.