Korean investigators presented a case of chronic inflammatory epidural granuloma formed after acupuncture. A 68-year-old woman suffered from low back pain and sciatica aggravated by acupuncture. Microscopic examination revealed the mass as a chronic inflammatory granuloma. From her previous history and imaging study, the mass, which compressed the lumbar forth nerve and dural sac, was highly suspected to have been formed after acupuncture. Surgical decompression and excision of the epidural mass relieved her symptoms. The authors concluded that chronic inflammatory granuloma may be formed as a complication of acupuncture. Under such circumstances, surgical excision of the mass may be an effective way of relieving the symptoms.