Since grape-seed extract has been shown to stimulate lipolysis in vitro and reduce food intake in rats, Dutch investigators assessed the efficacy of grape-seed extract with respect to energy intake (EI) and satiety. In a randomised, placebo-controlled, double-blind, crossover study, 51 subjects (age 18–65 years, body-mass index 22–30 kg/m²) ate an ad libitum lunch and dinner twice in the university restaurant for 3 days. Standard breakfasts and snacks were provided. Supplements were taken 30–60 min prior to each meal. In the total study population, no difference in 24 h EI was found between the grape-seed extract and placebo. However, in the subgroup of subjects (n = 23) with an energy requirement greater than or equal to the median of 7.5 MJ/day, EI was reduced by 4% (change in EI = 352.1 kJ/24h) after grape-seed extract compared to placebo treatment. Meanwhile, there were no significant differences in macronutrient composition, attitude towards eating, satiety, mood or tolerance.