This study aimed to evaluate the effect of a GP-led homoeopathy service on symptoms, activity, well-being, general practice consultation rate and the use of conventional medications. Data were collected for 97 consecutive patients referred between 1 July 2002 and 23 January 2003. Self-rated symptom severity, activity limitation and well-being were scored on a seven-point scale at initial homoeopathic consultation and via postal questionnaire at a mean follow-up time of 134 days. Primary symptoms improved by a mean of 2.49 points, secondary symptoms by 2.49 points, ability to undertake activity by 2.43 points and well-being by 1.41 points. Following use of the homoeopathy service the mean 6-month general practice consultation rate decreased by 1.18 consultations per patient. In all 57% of patients reduced or stopped taking their conventional medication, saving £2807.30. The main limitation of this study is the absence of a control group. The findings warrant further research, including controlled studies and economic analysis.