Infants with neonatal cerebral insults are susceptible to excessive crying as a result of difficulties with self-regulation. The aim of this study was to compare the effectiveness of swaddling vs. massage therapy in the management of excessive crying of infants with cerebral insults. A randomised 3-week parallel comparison was initiated to examine the efficacy of two intervention methods. Infants with symptoms of troublesome crying and their parents were randomly assigned to a swaddling intervention group (n = 13) or a massage intervention group (n = 12). The amount of total daily crying decreased significantly in the swaddling group, but did not decrease significantly in the massage group. Infant behavioural profiles and maternal anxiety levels improved significantly in the swaddling group post-intervention. Parents in the swaddling group were more satisfied with the effectiveness of the intervention in reducing crying than parents in the massage group.