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Focus on Alternative and Complementary Therapies
Home > FACT > FACT contents > Volume 9 2004 > Volume 9:4 December 2004 > Short Reports > Herbal Medicine

Focus Altern Complement Ther 2004; 9: 321

Herbal Medicine

More on Chinese herb nephropathy

Chinese herb nephropathy includes a variety of clinical features of progressive renal failure to the variant type of Fanconi’s syndrome. Fanconi’s syndrome has mostly been reported in Asian countries and is characterised by proximal tubular dysfunction and slower progression to end-stage renal disease; it also often reveals a reversible clinical course. Korean nephrologists describe a 43-year-old woman who presented with polyuria and polydipsia caused by Fanconi’s syndrome. The cause of Fanconi’s syndrome was not identified because the patient initially denied the intake of the Chinese herbal mixture. Fanconi’s syndrome seemed to be reversible in its early stage, but it rapidly progressed to renal failure after 3 months, despite the interruption of Chinese mixture use. A renal biopsy revealed typical findings of aristolochic acid-induced nephropathy. Aristolochic acids were also detected in the Chinese herbs that were consumed.

Lee S, Lee T, Lee B et al. Fanconi’s syndrome and subsequent progressive renal failure caused by a Chinese herb containing aristolochic acid. Nephrology (Carlton) 2004; 9: 126–9. [Abstract]
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