Focus on Alternative and Complementary Therapies
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Focus Alternat Complement Ther©2005 Pharmaceutical Press
Focus Altern Complement Ther 2004; 9: 321
Chinese herb nephropathy includes a variety of clinical features of progressive renal failure to the variant type of Fanconi’s syndrome. Fanconi’s syndrome has mostly been reported in Asian countries and is characterised by proximal tubular dysfunction and slower progression to end-stage renal disease; it also often reveals a reversible clinical course. Korean nephrologists describe a 43-year-old woman who presented with polyuria and polydipsia caused by Fanconi’s syndrome. The cause of Fanconi’s syndrome was not identified because the patient initially denied the intake of the Chinese herbal mixture. Fanconi’s syndrome seemed to be reversible in its early stage, but it rapidly progressed to renal failure after 3 months, despite the interruption of Chinese mixture use. A renal biopsy revealed typical findings of aristolochic acid-induced nephropathy. Aristolochic acids were also detected in the Chinese herbs that were consumed.