An RCT was conducted to investigate whether an osteopathic treatment of the chronic Epicondylopathia humeri radialis (EHR) reduces pain more effectively than an orthopaedic treatment. Fifty-three patients were randomly distributed among examination and control groups, and treated for 8 weeks. The osteopathic treatment was done exclusively manually, with parietal, visceral and craniosacral techniques, individually chosen for each patient. The orthopaedic treatment was performed with chiropractic techniques, antiphlogistics and mostly with injections of cortison. Four common tests were used, all four valuing pain and development of power:pressure pain test, Thomsen test, middle finger extension test and test for strength. Additionally a questionnaire about the attendant circumstances of the chronic EHR was used. Subjective pain sensation reduced from 50 to 33% in the intervention group and from 48 to 32% in the orthopaedic group. A reduction of pain as well as an increase of power was measured. The difference between the two treatment methods, however, was not statistically significant.