The objectives of this study included examining massage therapy for women with breast cancer for improving mood and biological measures associated with mood enhancement (serotonin and dopamine), reducing stress and stress hormone levels and boosting immune measures. Thirty-four women diagnosed with stage 1 or 2 breast cancer were randomly assigned post-surgery to a massage therapy group (to receive 30-min massages three times per week for 5 weeks) or a control group. The massage consisted of stroking, squeezing and stretching techniques to the head, arms, legs/feet and back. On the first and last day of the study, the women were assessed on immediate effects measures of anxiety, depressed mood and vigour, and longer-term effects on depression, anxiety and hostility, functioning, body image and avoidant vs. intrusive coping style, in addition to urinary catecholamines (norepinephrine, epinephrine and dopamine) and serotonin levels. A subset of 27 women (n = 15 massage) had blood drawn to assay immune measures. The immediate massage therapy effects included reduced anxiety, depressed mood and anger. The longer-term massage effects included reduced depression and hostility, and increased urinary dopamine, serotonin values, NK cell number and lymphocytes.