Twenty multiple sclerosis patients (14 female, 6 male) were involved in this study. Ten participants formed the therapy group and 10 the matched control group matched by age, gender and the standard neurological classification scheme Expanded Disability Status Scale (EDSS). Patients in the therapy group received three blocks of music therapy in single sessions over the course of the 1-year project (8–10 sessions). Measurements were taken before therapy began and subsequently every 3 months and within a 6-month follow-up without music therapy after the last consultation. The test battery included indicators of clinical depression and anxiety (Beck Depression Inventory and Hospital Anxiety and Depression Scale), a self-acceptance scale and a life quality assessment (Hamburg Quality of Life Questionnaire in Multiple Sclerosis). In addition, data were collected on cognitive (Multiple Sclerosis Functional Composite) and functional (EDSS) parameters. There was no significant difference between the music-therapy treatment group and the control group. However, the effect size statistics comparing both groups showed a medium effect size on the scale measuring self-esteem, and the Hospital Anxiety and Depression Scale –Depression, Hospital Anxiety and Depression Scale –Anxiety.