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FACT
Focus on Alternative and Complementary Therapies

Effect of Sho-Seiryu-To on skin itching and peripheral eosinophilia in elderly patients

Murata K1,2, Toriumi Y3, Kamei T1,2
1Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Japan
2Shimane Institute of Health Science, 223-7 Enya-cho, Izumo, Japan
3Department of Pediatrics, Shimane University, 89-1 Enya-cho, Izumo, Japan

Objective

Antihistamine and anti-allergic drugs are generally prescribed to control itching, but their effectiveness can occasionally be questioned. Traditional herbal medicine has proven effective in several skin diseases with severe itching. Sho-Seiryu-To (Xiao-Qing-Long-Tang in Chinese), consists of eight component traditional herbs and can treat the common cold, bronchial asthma and allergic rhinitis. However, its effectiveness against skin itching has not been reported. In addition, Sho-Seiryu-To has been reported to exhibit inhibitory effects upon eosinophil viability and degranulation. Thus, we administrated Sho-Seiryu-To to elderly patients with skin itching and peripheral eosinophilia despite using antihistamine drugs.

Materials and methods

We administrated Sho-Seiryu-To (Kotaro Sho-seiryu-to N19: 7.5 g/day) to three elderly patients with skin itching and peripheral eosinophilia despite using antihista-mine drugs. We assessed the effects of Sho-Seiryu-To on skin symptoms and the peripheral eosinophil level.

Results

In our cases, when the peripheral eosinophil levels were greatest, the skin symptoms were severest. Sho-Seiryu-To improved the skin symptoms along with a decrease of peripheral eosinophilia in these cases. Except for one case of dry mouth, there were few side-effects.

Conclusion

Sho-Seiryu-To was considered to be effective in treating elderly patients with chronic skin itching and peripheral eosinophilia. Few side-effects were seen.

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