This double-blind RCT compared the effectiveness of ginger (not specified) and vitamin B6 for the treatment of nausea and vomiting in early pregnancy. Pregnant women with nausea, who first attended the antenatal clinic at or before 17 weeks’ gestation, were invited to participate in the study. Over a 3-month period, 70 women were randomised to receive either ginger 1 g/day or vitamin B6 40 mg/day for 4 days. Subjects graded the severity of their nausea using a VAS, and recorded the number of vomiting episodes in the 24 h before treatment and during 4 consecutive days while taking treatment. At 7-day follow-up, women reported any changes in the severity of their symptoms. When compared with baseline, the decrease in the VAS of post-therapy nausea in the ginger group was significantly greater than that for the vitamin B6 group. The number of vomiting episodes decreased in both groups, and there was no significant difference between the groups. In the ginger group, 29/35 women reported an improvement in nausea symptoms, compared with 23/34 women in the vitamin B6 group.